The couple married at Boone Hall Plantation in a celebration that included a performance by Florence Welch of Florence and the Machine fame, People reports.
Reynolds, 35, was previously married to Scarlett Johansson, but their union ended after two years in 2010. This is the first marriage for the 25-year old Lively.
Reynolds is slated to appear in next summer's futuristic thriller "R.I.P.D" and Lively is filming the final season of her CW show "Gossip Girl."
Representatives for the two actors did not immediately respond to requests for comment.