The actress will play herself in an April episode of Sheen's FX sitcom "Anger Management." She will be treated by Sheen's character, a therapist, and the two develop a romantic relationship.
Sheen and Lohan also recently worked together in the upcoming "Scary Movie 5" (pictured), also set to debut in April.
Their relationship isn't merely professional: In November, Sheen's publicist told TheWrap that he gave Lohan $100,000 to help pay her taxes.
Lohan, who recently appeared in Lifetime's "Liz & Dick," also appears in the upcoming film "The Canyons."