Akerman & Ambrose Join Rudd & Aniston in ‘Wanderlust’

David Wain is directing the Universal comedy from a script he co-wrote with Ken Marino

"Watchmen" star Malin Akerman and Lauren Ambrose (HBO's "Six Feet Under") have been cast alongside Paul Rudd, Jennifer Aniston and Justin Theroux in the Universal comedy "Wanderlust," reports Variety.

David Wain ("Role Models") directs from a script he co-wrote with Ken Marino, a fellow veteran of MTV's "The State." The duo also will produce with Rudd and Judd Apatow, while Dick Vane will exec produce.

Rudd and Aniston star as a married couple who try to escape modern society by leaving their cushy lives in New York.

While it's unclear what role Akerman will inhabit, the underappreciated Ambrose will play a member of the freewheeling commune that the two stars come into contact with en route to Atlanta.

Ambrose, Rudd and Marino previously starred together in Katherine Dieckmann's little-seen indie "Diggers."

Erik Baiers will oversee "Wanderlust" for the studio.

Akerman recently attached herself to the CIA thriller "The Numbers Station," which star Ethan Hawke is producing, and she's also set to star opposite Bruce Willis in the thriller "Catch 44." The actress currently has "The Romantics" in theaters and "The Bang Bang Club" at Toronto.

Ambrose recently voiced a character in "Where the Wild Things Are," and she also co-starred with Paul Giamatti in the sci-fi indie "Cold Souls."

Akerman is represented by WME and Sanders Armstrong Caserta Management, while Ambrose is repped by UTA and Kipperman Management.