Should a deal make, Fox would be back in business with McAvoy, who played Professor X the studio's blockbuster "X-Men: First Class" and reprises the role in Bryan Singer's upcoming "X-Men: Days of Future Past."
McAvoy is in talks play Victor Von Frankenstein, a coveted role that Jack Huston ("Boardwalk Empire") and Toby Kebbell ("RocknRolla") recently tested for. While Huston and Kebbell both have bright careers ahead of them, neither provided the star-power necessary to have justified the budget.
Radcliffe is set to play Igor, and his pairing with McAvoy makes "Frankenstein" a safe bet for the studio.
Fox's "Chronicle" screenwriter Max Landis has updated Mary Shelley's classic mythology, and John Davis is producing the movie through his Davis Entertainment banner.
McAvoy recently starred in Danny Boyle's "Trance" and the indie thriller "Welcome to the Punch." He'll soon be seen opposite Jessica Chastain in the two-part indie movie "The Disappearance of Eleanor Rigby," as well as a feature adaptation of Irvine Welsh's novel "Filth."
McAvoy is repped by UTA.