Tentatively titled "Get a Job," the film will focus on four recent college graduates and their difficulties adjusting to life outside the ivy tower.
Harden will play a demanding vice president at an executive placement firm.
Harden won an Oscar for her work as artist Lee Krasner in "Pollock" and received another nomination for her performance in "Mystic River." She has also appeared in "The Mist," "Meet Joe Black," and "Whip It," and won a Tony for performance in "God of Carnage."
The film began production on March 12th in Los Angeles.