In a statement, Lionsgate, which produces "Anger Management," said that it wishes Blair "the very best."
“We are confirming that Selma Blair will not be returning to 'Anger Management' and we wish her the very best.”
Though Lionsgate didn't elaborate on Blair's departure, the announcement comes following reports that Sheen had demanded that Blair be fired, after she found herself on Sheen's bad side. According to TMZ, Sheen offered an ultimatum to "Anger Management" producers, saying that he would quit if Blair wasn't fired. Sheen reportedly believed that Blair had been complaining about his work habits behind his back.
Blair played Dr. Kate Wales, a therapist and the frequent bedmate of Sheen's Charlie Goodson character on the series, which is currently in its second season.
Blair's publicist has not yet responded to TheWrap's request for comment.
TMZ also reported earlier this week that Sheen is trying to book "Black Swan" star Mila Kunis for a 10-episode guest arc on the series — an interesting development, if true, given that Kunis has been romantically linked to her former "That '70s Show" co-star Ashton Kutcher, who replaced Sheen on "Two and a Half Men."
After gaining satisfactory ratings with its first 10-episode season, "Anger Management" was renewed for another 90 episodes.