"Love You, Mean It With Whitney Cummings" premiered in November
"Production has completed on 'Love You, Mean It With Whitney Cummings,' and the last episode aired last Wednesday," an E! spokeswoman said in a statement.
The weekly series, which premiered in late November, was executive-produced by Cummings and Chelsea Handler.
Cummings still has her NBC sitcom, "Whitney," which is currently in its second season.