But Jon Stewart was there with two pints of ice cream goodness to try to pick up the pieces.
"The last time I had a bad break-up, Ben & Jerry’s got me through some of the tougher times," Stewart told Pattinson.
"We’re just a couple of gals talking… tell me everything,” he coaxed.
Pattinson, who emerged from his recent self-imposed exile to promote his upcoming film "Cosmopolis," never mentioned Stewart by name and never alluded to the cheating scandal with her "Snow White and the Huntsman" director Rupert Sanders.
But he acknowledged one mistake.
"My biggest problem in my life is I’m cheap and I didn't hire a publicist," Pattinson said.
Stewart didn't really press the "Twilight" actor to bare his heart, but he did offer some sage advice about the outpouring of global grief that greeted the news of Stewart's two-timing ways.
"When you are young and you break up, it's powerful and it feels like the world is ending," Stewart said. "This is the first time I have seen the world actually react that way."