(Spoiler alert: Please do not read on if you haven’t watched the Season 9 premiere of “The Big Bang Theory”)

Is it going to be happily ever after for Penny (Kaley Cuoco-Sweeting) and Leonard (Johnny Galecki) on the “Big Bang Theory?”

Sadly, even the smart physicists on the hit CBS sit-com don’t have a simple formula for a perfect marriage as the lovebirds got off to a bumpy start on the Season 9 premiere Monday.

Also Read: Kaley Cuoco-Sweeting Wins Puppy Cuddles by Taking on Jimmy Fallon in 'Pup Quiz' (Video)

Things were made decidedly trickier after Leonard confessed to kissing another woman, Mandy, on his North Sea expedition two years ago.

While the pair streamed their nuptials in a Las Vegas chapel online for their nerdy friends to watch, viewers took to Twitter to share their congratulations for the fictional newlyweds.

Also Read: 19 Biggest Emmy Snubs and Surprises: 'Empire,' Tatiana Maslany, and 'The Big Bang Theory' (Photos)

“The Big Bang Theory” airs Mondays at 8 p.m. on CBS.

See the tweets below.

The moment we've all been waiting for … The @BigBang_CBS Season 9 premiere!! Here … We … Go! #BigBangTheory

— Emilio Estevez (@EmilioEstevezCF) September 22, 2015

You got a friend in me vows… #Classic Thank you @BigBang_CBS for making me tear up! yay Penny and Leonard

— Christina Ochoa (@ChristinaJOchoa) September 22, 2015

Crying at the @BigBang_CBS wedding. How is your Monday going?

— Aly Keves (@alykeves) September 22, 2015

#BigBangTheory I'm so excited!!! #PennyAndLeonardWed

— Brenna (@Brendiemae) September 22, 2015

Yay #BigBangTheory time finally!!!

— Mandee (@MandeeMe) September 22, 2015

Say it ain't so #Shamy…. #BigBangTheory

— suzan189 (@suzan189) September 22, 2015

This is it! #PennyAndLeonardWed #BigBangTheory pic.twitter.com/N7JQwfLzoG

— The Big Bang Theory (@BigBang_CBS) September 22, 2015

Fall TV Preview: 126 New and Returning Shows Premiere Dates

“The Awesomes” (Hulu) Tuesday, Sept. 8
Hulu
“The Late Show With Stephen Colbert” (CBS) Tuesday, Sept. 8 at 11:35 p.m.
Getty Images
“The League” (FXX) Wednesday, Sept. 9 at 10 p.m.
FXX
“You’re the Worst” (FXX) Wednesday, Sept. 9 at 10:30 p.m.
FXX
“Longmire” (Netflix) Thursday, Sept. 10
Netflix
“Z Nation” (Syfy) Friday, Sept. 11 at 10 p.m.
Syfy
“Continuum” (Syfy) Friday, Sept. 11 at 11 p.m.
Syfy
“Project Greenlight” (HBO) Sunday, Sept. 13 at 10 p.m.
HBO
“Doll & Em” (HBO) Sunday, Sept. 13 at 10:40 p.m.
HBO
“Dancing With the Stars” (ABC) Monday, Sept. 14 at 8 p.m.
ABC
“The Mindy Project” (Hulu) Tuesday, Sept. 15
Hulu
“Best Time Ever With Neil Patrick Harris” (NBC) Tuesday, Sept. 15 at 10 p.m.
Getty Images
“The Bastard Executioner” (FX) Tuesday, Sept. 15 at 10 p.m.
FX
“South Park” (Comedy Central) Wednesday, Sept. 16 at 10 p.m.
Comedy Central
“Moonbeam City” (Comedy Central) Wednesday, Sept. 16 at 10:30 p.m.
Comedy Central
“Doctor Who” (BBC America) Saturday, Sept. 19
BBC America
“The Voice” (NBC) Monday, Sept. 21 at 8 p.m.
NBC
“Gotham” (Fox) Monday, Sept. 21 at 8 p.m.
Fox
“The Big Bang Theory” (CBS) Monday, Sept. 21 at 8 p.m.
CBS
“Life in Pieces” (CBS) Monday, Sept. 21 at 8:30 p.m.
CBS
“Minority Report” (Fox) Monday, Sept. 21 at 9 p.m.
Fox
“Scorpion” (CBS) Monday, Sept. 21 at 9 p.m.
CBS
“NCIS: Los Angeles” (CBS) Monday, Sept. 21 at 10 p.m.
CBS
“Castle” (ABC) Monday, Sept. 21 at 10 p.m.
ABC
“Blindspot” (NBC) Monday, Sept. 21 at 10 p.m.
NBC
“Scream Queens” (Fox) Tuesday, Sept. 22 at 8 p.m.
Fox
“NCIS” (CBS) Tuesday, Sept. 22 at 8 p.m.
CBS
“The Muppets” (ABC) Tuesday, Sept. 22 at 8 p.m.
ABC
“Fresh off the Boat” (ABC) Tuesday, Sept. 22 at 8:30 p.m.
ABC
“NCIS: New Orleans” (CBS) Tuesday, Sept. 22 at 9 p.m.
CBS
“Limitless” (CBS) Tuesday, Sept. 22 at 10 p.m.
CBS
“Survivor” (CBS) Wednesday, Sept. 23 at 8 p.m.
CBS
“Rosewood” (Fox) Wednesday, Sept. 23 at 8 p.m.
Fox
“The Mysteries of Laura” (NBC) Wednesday, Sept. 23 at 8 p.m.
NBC
“The Middle” (ABC) Wednesday, Sept. 23 at 8 p.m.
ABC
“The Goldbergs” (ABC) Wednesday, Sept. 23 at 8:30 p.m.
ABC
“Empire” (Fox) Wednesday, Sept. 23 at 9 p.m.
Fox
“Law & Order: SVU” (NBC) Wednesday, Sept. 23 at 9 p.m.
NBC
“Modern Family” (ABC) Wednesday, Sept. 23 at 9 p.m.
ABC
“black-ish” (ABC) Wednesday, Sept. 23 at 9:30 p.m.
ABC
“Nashville” (ABC) Wednesday, Sept. 23 at 10 p.m.
ABC
“Heroes Reborn” (NBC) Thursday, Sept. 24 at 8 p.m.
NBC
“Grey’s Anatomy” (ABC) Thursday, Sept. 24 at 8 p.m.
ABC
“Scandal” (ABC) Thursday, Sept. 24 at 9 p.m.
ABC
“The Player” (NBC) Thursday, Sept. 24 at 10 p.m.
NBC
“How to Get Away With Murder” (ABC) Thursday, Sept. 24 at 10 p.m.
ABC
“Last Man Standing” (ABC) Friday, Sept. 25 at 8 p.m.
ABC
“The Amazing Race” (CBS) Friday, Sept. 25 at 8 p.m.
CBS
“Hawaii Five-0” (CBS) Friday, Sept. 25 at 9 p.m.
CBS
“Shark Tank” (ABC) Friday, Sept. 25 at 9 p.m.
“Blue Bloods” (CBS) Friday, Sept. 25 at 10 p.m.
CBS
“Bob’s Burgers” (Fox) Sunday, Sept. 27 at 7:30 p.m.
Fox
“The Simpsons” (Fox) Sunday, Sept. 27 at 8 p.m.
Fox
“Once Upon a Time” (ABC) Sunday, Sept. 27 at 8 p.m.
ABC
“CSI: Crime Scene Investigation” Finale (CBS) Sunday, Sept. 27 at 8 p.m.
CBS
“Brooklyn Nine-Nine” (Fox) Sunday, Sept. 27 at 8:30 p.m.
Fox
“Family Guy” (Fox) Sunday, Sept. 27 at 9 p.m.
Fox
“Blood & Oil” (ABC) Sunday, Sept. 27 at 9 p.m.
ABC
“The Last Man on Earth” (Fox) Sunday, Sept. 27 at 9:30 p.m.
Fox
“Quantico” (ABC) Sunday, Sept. 27 at 10 p.m.
ABC
“The Daily Show With Trevor Noah” (Comedy Central) Monday, Sept. 28 at 11 p.m.
Comedy Central
“Marvel’s Agents of S.H.I.E.L.D.” (ABC) Tuesday, Sept. 29 at 8 p.m.
ABC
“Grandfathered” (Fox) Tuesday, Sept. 29 at 8 p.m.
Fox
“The Grinder” (Fox) Tuesday, Sept. 29 at 8:30 p.m.
Fox
“Beyond the Tank” (ABC) Tuesday, Sept. 29 at 10 p.m.
ABC
“Criminal Minds” (CBS) Wednesday, Sept. 30 at 9 p.m.
CBS
“Code Black” (CBS) Wednesday, Sept. 30 at 10 p.m.
CBS
“Chicago PD” (NBC) Wednesday, Sept. 30 at 10 p.m.
NBC
“Bones” (Fox) Thursday, Oct. 1 at 8 p.m.
Fox
“The Blacklist” (NBC) Thursday, Oct. 1 at 9 p.m.
NBC
“Sleepy Hollow” (Fox) Thursday, Oct. 1 at 9 p.m.
Fox
“Benders” (IFC) Thursday, Oct. 1 at 10 p.m.
IFC
“Dr. Ken” (ABC) Friday, Oct. 2 at 8:30 p.m.
ABC
“Saturday Night Live” (NBC) Saturday, Oct. 3 at 11:30 p.m.
NBC
“Madam Secretary” (CBS) Sunday, Oct. 4 at 8 p.m.
CBS
“The Leftovers” (HBO) Sunday, Oct. 4 at 9 p.m.
HBO
“Homeland” (Showtime) Sunday, Oct. 4 at 9 p.m.
Showtime
“The Good Wife” (CBS) Sunday, Oct. 4 at 9 p.m.
CBS
“CSI: Cyber” (CBS) Sunday, Oct. 4 at 10 p.m.
CBS
“The Affair” (Showtime) Sunday, Oct. 4 at 10 p.m.
Showtime
“The Flash” (CW) Tuesday, Oct. 6 at 8 p.m.
CW
“iZombie” (CW) Tuesday, Oct. 6 at 9 p.m.
CW
“Finding Carter” (MTV) Tuesday, Oct. 6 at 10 p.m.
MTV
"Casual" (Hulu) Wednesday, Oct. 7
Hulu
“Arrow” (CW) Wednesday, Oct. 7 at 8 p.m.
CW
“Supernatural” (CW) Wednesday, Oct. 7 at 9 p.m.
CW
“American Horror Story: Hotel” (FX) Wednesday, Oct. 7 at 10 p.m.
FX
“The Vampire Diaries” (CW) Thursday, Oct. 8 at 8 p.m.
CW
“The Originals” (CW) Thursday, Oct. 8 at 9 p.m.
CW
“Haven” (Syfy) Thursday, Oct. 8 at 10 p.m.
Syfy
“Funny or Die’s Billy on the Street” (truTV) Thursday, Oct. 8 at 10:30 p.m.
truTV
“Red Oaks” (Amazon) Friday, Oct. 9
Amazon
“Reign” (CW) Friday, Oct. 9 at 8 p.m.
CW
“Undateable” (NBC) Friday, Oct. 9 at 8 p.m.
NBC
“The Last Kingdom” (BBC America) Saturday, Oct. 10 at 10 p.m.
BBC America
“The Walking Dead” (AMC) Sunday, Oct. 11 at 9 p.m.
AMC
“The Talking Dead” (AMC) Sunday, Oct. 11 at 10:30 p.m.
AMC
“Crazy Ex-Girlfrind” (CW) Monday, Oct. 12 at 8 p.m.
CW
“Jane the Virgin” (CW) Monday, Oct. 12 at 9 p.m.
CW
“Fargo” (FX) Monday, Oct. 12 at 10 p.m.
FX
“Manhattan” (WGN) Tuesday, Oct. 13 at 9 p.m.
WGN
“Chicago Fire” (NBC) Tuesday, Oct. 13 at 10 p.m.
NBC
“Kingdom” (DirecTV) Wednesday, Oct. 14 at 9 p.m.
DirecTV
“Nathan for You” (Comedy Central) Thursday, Oct. 15 at 10 p.m.
Comedy Central
“The Knick” (Cinemax) Friday, Oct. 16
Cinemax
“Truth Be Told” (NBC) Friday, Oct. 16 at 8:30 p.m.
NBC
“Satisfaction” (USA) Friday, Oct. 16 at 10 p.m.
USA
“Please Like Me” (Pivot) Friday, Oct. 16 at 10 p.m.
Pivot
“RocketJump: The Show” (Hulu) Wednesday, Oct. 21
Getty Images
“Hemlock Grove” (Netflix) Friday, Oct. 23
Netflix
“Da Vinci’s Demons” (Starz) Saturday, Oct. 24 at 8 p.m.
Starz
“Supergirl” (CBS) Monday, Oct. 26 at 8:30 p.m.
CBS
“Wicked City” (ABC) Tuesday, Oct. 27 at 10 p.m.
ABC
“Grimm” (NBC) Friday, Oct. 30 at 10 p.m.
NBC
“Ash vs. Evil Dead” (Starz) Saturday, Oct. 31 at 9 p.m.
Starz
“Major Crimes” (TNT) Monday, Nov. 2 at 9 p.m.
TNT
“Legends” (TNT) Monday, Nov. 2 at 10 p.m.
TNT
“Angel From Hell” (CBS) Thursday, Nov. 5 at 9:30 p.m.
CBS
“Mom” (CBS) Thursday, Nov. 5 at 9 p.m.
CBS
“Elementary” (CBS) Thursday, Nov. 5 at 10 p.m.
CBS
“Master of None” (Netflix) Friday, Nov. 6
Getty Images
“MasterChef Junior” (Fox) Friday, Nov. 6 at 8 p.m.
Fox
“Flesh and Bone” (Starz) Sunday, Nov. 8
Starz
“Chicago Med” (NBC) Tuesday, Nov. 10 at 10 p.m.
NBC
“Donny!” (USA) Tuesday, Nov. 10 at 10:30 p.m.
USA
“Into the Badlands” (AMC) Sunday, Nov. 15 at 10 p.m.
AMC
“The Man in the High Castle” (Amazon) Friday, Nov. 20
Amazon