David Letterman walked out to thunderous applause and a standing ovation during his final night as host of CBS’ “Late Show.”

Letterman signs off from the “Late Show” desk after 22 years, making way for Stephen Colbert, who takes over on Sept. 8.

The Foo Fighters will be the final musical guest to appear on Letterman’s show Wednesday night, which will also feature a star-studded Top Ten List, highlights from his long run and surprise appearances.

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While no other guests have been announced, some of Letterman’s celebrity friends have already put in their two cents on his retirement.

Bill Murray popped out of a cake to say goodbye to Dave on Tuesday night, coating him with eggs, sugar, flour and whatever icing is made of in the process. He then spent the next few segments trying to convince his pal to stay in the game.

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Over his 22 years at the desk, Letterman won six Emmys, the last in 2002.

Watch the video of his final entrance above.

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The final episode of CBS’ “The Late Show With David Letterman” will air Wednesday night at 11:35 p.m. ET.