WHAT'S UP DOC? (1972)
Barbra Streisand updates Hepburn for the '70s, as a vagabond trouble maker with her eye on Ryan O'Neal. She burns down a hotel room, sets off a high-speed chase through the streets of San Francisco and destroys his relationship with his fiancée, but O'Neal still falls in love with her. You will too.
From ‘His Girl Friday’ to ‘The Heat’: The Evolution of Female Comedies (Photos)
From Katherine Hepburn in "Bringing Up Baby" to Melissa McCarthy in "The Heat," here's a look at some of the greatest female characters in film history.