Production begins Tuesday on the pilot following two women (Slate and Graynor) who become friends, make a movie together and proceed to embark on a cross-country road trip.
Robespierre is directing the untitled pilot she co-wrote with Holm, and the two will also serve as executive producers along with Slate and A24 Films' Ravi Nandan and John Hodges.
The team previously collaborated on 2014's "Obvious Child," which marked Robespierre's feature directorial debut and starred Slate as an aspiring comedienne faced with a life-changing decision.
Slate, an alum of "Saturday Night Live," currently co-stars on FX's "Married," which returns for Season 2 on July 16. Graynor most recently headlined CBS' "Bad Teacher" series adaptation.
Slate is represented by WME, 3 Arts Entertainment, and Josh Sandler at Gray Krauss Stratford Sandler Des Rochers.
Graynor is repped by UTA, Authentic Talent and Literary Management and Lichter, Grossman, Nichols, Adler & Feldman.
Robespierre and Holm are both represented by UTA.