The character is one of Peter Parker's most infamous villains, and was portrayed by Willem Dafoe in Sam Raimi's "Spider-Man" trilogy. "Chronicle" star Dane DeHaan has already been cast as Harry Osborn, who is Norman's son and Parker's best friend.
Also read: Dane DeHaan Tapped for Next 'Amazing Spider-Man'
Spider-Man, played by Andrew Garfield, will have his hands full in his next big-screen adventure, as it's been previously announced that he'll be facing off against Jamie Foxx ("Django Unchained") as Electro and Paul Giamatti ("Sideways") as the Rhino.
The teenage superhero will also be juggling multiple romantic relationships, too. Emma Stone is returning as Gwen Stacy, while Shailene Woodley ("The Descendants") is portraying Mary Jane Watson — a character previously played by Kirsten Dunst.
Production for the second film in the planned trilogy is already underway, with its release scheduled for May 2, 2014.
Cooper, an Academy Award winner in 2002 for best supporting actor in "Adaptation," was seen in theaters as the maniacal oil executive Tex Richman in 2011's "The Muppets," and will next appear in "August: Osage County."