TheWrap takes a look at the 12-year history of the Hollywood power couple.
2004: "Mr. and Mrs. Smith"
Jolie and Pitt meet on the set of Doug Liman's "Mr. and Mrs. Smith," where she said they "fell in love." At the time, Pitt was married to Jennifer Aniston and Jolie's divorce from Billy Bob Thornton had been finalized in 2003.
During promotional appearances for "Mr. and Mrs. Smith," Jolie and Pitt kept their distance. A week later, Aniston filed for divorce following their separation announcement in January.
April 2005: Vacation with Maddox
Jolie gets photographed on vacation in Kenya with her son, Maddox.
June 2005: W Magazine Spread
The two actors were featured in a W magazine spread titled "Domestic Bliss," which stirred up controversy given that the photos were taken a few months after Pitt's split from Aniston.
July 2005: Jolie Adopts Zahara
The actress adopts Zahara from Ethiopia. According to Popsugar, Zahara was first adopted as a single parent but it was later revealed that Pitt filed to legally adopt both Zahara and Maddox and to officially change their last name to Jolie-Pitt.
January 2006: Jolie Is Pregnant
Jolie confirms she is pregnant with Pitt's first biological child. Shiloh was born in May.
December 2006: First Red Carpet
The couple walked the red carpet together for the first time as an official couple at the NYC premiere of Jolie's "The Good Shepherd."
March 2007: Duo Adopt Pax
Jolie and Pitt adopt son Pax from Vietnam.
May 2008: Couple Is Expecting Twins
At the Cannes Film Festival in May of 2008, it was revealed that the two were expecting twins.
July 2008: Knox and Vivienne Are Born
The twins Knox and Vivienne were born in Nice, France. The couple and the twins were featured on the August cover of People magazine.
January 2010: Divorce Rumors
British tabloid News of the World starts rumors that Pitt and Jolie were divorcing. They sued the paper as the publication declined to retract allegations. They won the lawsuit.