Carey Mulligan has turned down the role of Hillary Clinton in the upcoming biopic, "Rodham."
Courteney Love said daughter Francis Bean Cobain turned down the role of Bella Swan in the blockbuster "Twilight Sage" franchise, saying the fame would've destroyed then 13-year-old Cobain's life.
Although Jack Nicholson said he knew "The Godfather" would be a great film, he turned down the role of Michael Corleone because he thought it should go to an Italian.
Having gotten the iconic role of "The Godfather" because Nicholson turned it down, Al Pacino made way for Richard Gere to step into the shoes of the leading man in "Pretty Woman," saying the role was poorly written.
Two of the biggest hits of Sandra Bullock's career, "The Proposal" and "The Blind Side," were supposed to go to another "Pretty Woman." Julia Roberts reportedly declined rom-com "The Proposal" because she wanted a bigger paycheck, and had no interest in "The Blind Side," which gave Bullock an Oscar.
Will Smith has been a part of some of the biggest blockbusters of all time, but he could've been a part of one more. Smith turned down the role of Neo in "The Matrix," who he said Keanu Reeves played perfectly. He admitted the script was too hard to follow and that he would've messed it up.
Matt Damon could've been a part of two of the highest-grossing movies of all time, "Avatar" and "The Dark Knight," but had to turn them down because he was busy filming other projects at the time ("The Bourne Ultimatum" and "Invictus," respectively).
"Se7en" was the first David Fincher and Brad Pitt collaboration, leading the way to "Fight Club" and "The Curious Case of Benjamin Button," but that partnership may have been very different if Denzel Washington had accepted the role of Detective David Mills. Washington said he thought "Se7en" to be too dark, but admitted he regretted his decision.
Jodie Foster's performance as Clarice Starling in "The Silence of the Lambs" is often considered to be her best work in a long career, but the actress wouldn't have gotten it if Michelle Pfeiffer hadn't refused it first. Pfieffer said she found the film too violent, dark, and disturbing.
Kevin Costner passed on the iconic role of Andy Dufresne in "The Shawshank Redemption" to concentrate on his passion project "Waterworld," which was a massive flop.
Tom Hanks has been "Big," "Cast Away," and "Forrest Gump," but he could've been "Jerry Maguire" too. The role eventually went to another Tom, Cruise, and Hanks has since said it couldn't have been anyone but Cruise.
Hanks almost wasn't "Forrest Gump" though. The role that won him an Oscar nearly went to John Travolta who has admitted he regrets his decision to turn it down.
Television has given way to household names, too. Sarah Jessica Parker's career was launched by "Sex and the City," but it could've been a different story if Dana Delany took the part originally offered to her. She said she did not want to do something relating to sex. She confessed she later regretted her decision.
Sweet Joey Potter of "Dawson's Creek" and the take-no-prisoners Buffy of the "Buffy the Vampire Slayer" could have been the same person. However, Katie Holmes declined the role to finish high school.
Tom Selleck said no to being "Baywatch's" Mitch Buchannon because he didn't want to be seen as a sex symbol, which allowed David Hasselhoff to take his place.
Gillian Anderson has revealed before she took on the role of Dana Scully on "The X-Files," producers were considering another Anderson, Pamela. Gillian explained the producers decided on her because they wanted to go down a completely different route. (No kidding!)
Al Pacino could have been Han Solo before Harrison Ford was offered the role -- if only the Oscar-winning actor could comprehend what the Force was. "It was mine for the taking, but I didn't understand the script," he told London audiences during this month's "An Evening With Pacino" event.