Lenny Bruce, the outrageous king of the counterculture comics in the 1950s and '60s, died at age 40 in 1966 of "acute morphine poisoning caused by an overdose."
, well known for his toga-loving frat boy performance in "Animal House," died at 33 of a drug overdose in 1982.
Gilda Radner, beloved for her tenure on "SNL" especially for her hilariously geeky character, Roseanne Roseannadanna, died at 42 in 1989 of ovarian cancer.
Andy Kaufman, the eccentric performance artist who gained a following as Latka in "Taxi," died in 1984 at age 35.
Sam Kinison was a rock star of a comic with a trademark shout. After years of battling substance abuse, he was sober and a newlywed of less than a week when he was struck and killed by a teenager driving drunk in 1992. He was 38.
, the lovable comedic actor renowned for his performances in "Uncle Buck," "Home Alone," "Planes, Trains and Automobiles" and "Cool Runnings" died at age 43 of a heart attack in 1994.
Bill Hicks, one of the most influential stand-up comics, died in 1994 of pancreatic cancer. He was 32.
, an SNL star, notorious for his over-the-top performances, especially his motivational speaker character Matt Foley, died in 1997 of a drug overdose. He was 33.
, star of "SNL," "NewsRadio" and "The Simpsons" died at age 49 in 1998 of an apparent murder-suicide by his wife.
Academy Award-nominated comedienne, Madeline Kahn
, one of the most influential women in comedy to grace the silver screen, died in 1999 of ovarian cancer. She was 57.
The prolific comedic actor, John Ritter
, best known for his role of Jack Tripper on "Three's Company" and the patriarchal figure in "8 Rules for Dating My Daughter," died of a heart attack in 2003. He was 54.
Mitch Hedberg, who gained a following of loyal fans for his unconventional stand-up comedy style, died in 2005 at age 37 of a drug overdose.
Richard Jeni, an improv comic best known for his role in "The Mask" died in 2007 at age 49.
, the stand up comic legend and star of "Ocean's Eleven" died at age 50 in 2008 of complications from pneumonia.
Greg Giraldo, the roast comic made famous by Comedy Central died in 2010 at age 44 of a prescription overdose.
, who gave a memorable roast of Charlie Sheen
and starred in many Comedy Central specials, died following a stroke in 2011. He was 41.
Mike DeStefano, finalist on "Last Comic Standing" and frequent Comedy Central performer, died of a heart attack in 2011. He was reportedly in his 40s.
Jay Leggett, who was known to many for his comedic stylings on "In Living Color" died of a heart attack in 2013. He was 50.
was found dead in a Pittsburgh hotel room in 2014. It is believed the actor, recognizable for getting mugged in the "Seinfeld" series finale, suffered from a pulmonary embolism. He was 50.