"Hangover Part III" centers around the Wolfpack hunting down old foe Mr. Chow, while new foe John Goodman holds Doug (Justin Bartha) hostage, according to the newest trailer for the Warner Bros. comedy.
The trouble all starts when Doug, Phil (Bradley Cooper) and Stu (Ed Helms) stage an intervention for Alan (Zach Galifianakis), who is an emotional mess after losing his dad (Jeffrey Tambor) and avoiding his medication for six months.
Also read: 'Hangover Part III' Poster Parodies 'Harry Potter' (Photos)
While en route to his rehabilitation center, the gang is rammed off a desert road by Goodman and given an ultimatum.
"Leslie Chow stole $21 million from me," Goodman explains. "I figure the Wolfpack has the best chance of finding him. Doug is my insurance."
And there goes Doug. Again.
Watch preview of the final "Hangover" hijinks below: