Rivers made her first appearance on "The Tonight Show with Johnny Carson" on February 17, 1965. By 1983, she had become the permanent guest host.
Michael J. Fox, Whoopi Goldberg and Joan Rivers blow out candles after a taping of the 100th episode of "The Late Show Starring Joan Rivers" (1987)
She appeared with Don Rickles on "The Kraft Music Hall" in 1968
Rivers in a 1983 episode of "Saturday Night Live" with Eddie Murphy
Rivers was the permanent guest host of "The Tonight Show with Johnny Carson." She interviewed plenty of celebrities, including Pee Wee Herman, in 1985
Rivers voiced the animated character Annie Dubinsky on a 2011 episode of "The Simpsons"
In 1986, Johnny Carson banned Rivers from "The Tonight Show" after she landed her own talk show "The Late Show Starring Joan Rivers."
She won Season 8 of Donald Trump's business-oriented reality game show, "The Apprentice"
Rivers performing stand-up at the Seminole Hard Rock Hotel & Casino in 2008 in Hollywood, Fla. in 2008
Kathy Griffin appears on stage at the "Comedy Central Roast of Joan Rivers" (2009)
She voiced C3P0-knockoff Dot Matrix in Mel Brooks' 1987 comedy "Spaceballs."
Tara Reid and Rivers prepare for the ALS Ice Bucket Challenge
Rivers with her daughter Melissa Rivers in 1990.
Rivers voiced herself in DreamWorks' smash-hit sequel "Shrek 2" 2004
She wrote "Bouncing Back: I've Survived Everything...and I Mean Everything...and You Can Too!" in 1997
Ricki Stern and Anne Sundberg directed a 2010 documentary about the comedienne's first 75 years on Earth
Rivers played herself in "Tears and Laughter: The Joan and Melissa Rivers Story"
Joan Rivers voiced the role of baby Julie at the end of "Look Who's Talking" in 1989, but the role was given to Roseanne Barr in the 1990 sequel "Look Who's Talking Too"
Joan and Melissa Rivers in Cannes in the early 2000s
Rivers shows off the Daytime Emmy she won in 1990 for "The Joan Rivers Show"
Rivers was a founding member of "Fashion Police," which first aired in 2010
The comedienne was finally allowed to return to "The Tonight Show" (now with Jimmy Fallon hosting) in 2014, 49 years after her banning by Johnny Carson
She starred alongside Louis C.K. in a memorable 2011 episode of his hit FX series "Louie"
Rivers in bed with her dog Spike
Rivers posted a tribute to Robin Williams shortly after his death, calling him "an amazing talent, a giving man, a brilliant comedian and an extraordinary actor"
Rivers with Lucille Ball: "Her last name should have been "Balls" because she sure had them. She fought her way to the top in a man's world and won," said Rivers on her Instagram account.
While interviewing Oprah Winfrey in 1985, Rivers suggested her colleague "must lose the weight"
One of the comedienne's final TV appearances on NBC's "Late Night with Seth Meyers" in August
Rivers appears with Andy Cohen on "Watch What Happens Live"