Cornell "Cottonmouth" Stokes (Mahershala Ali)
The show's main villain, Cornell (don't call him Cottonmouth) runs most of the rackets in Harlem out of his nightclub, Harlem's Paradise. But his operation starts to unravel when a gun deal goes south and Luke Cage starts to investigate him.
Mariah "Black Mariah" Stokes(Alfre Woodard)
Mariah is the cousin of Cornell and a city council member representing Harlem. She uses money that Cornell provides her to fund her various charitable initiatives throughout the community.
Shades Alvarez (Theo Rossi)
Shades is a "criminal consultant" in the employ of the mysterious arch-criminal Diamondback. He is sent to help Cottonmouth when his control over Harlem starts to wain.
Det. Rafael Scarfe (Frank Whaley)
Scarfe is a veteran cop with a strange sense of humor. He is Knight's longtime partner who schooled her in the ways of good detective work.
Claire Temple (Rosario Dawson)
Fans of the Marvel/Netflix universe will remember Temple as the nurse who assisted both Daredevil and Jessica Jones. She takes up the same role here, this time offering help and guidance to Cage.
Willis "Diamondback" Stryker (Erik LaRay Harvey)
Little has been revealed about Diamondback thus far, other than he is a highly-feared criminal who provides support to Cottonmouth when needed. In the comics, he is an old friend of Cage's who is a master of knives.