Cage was blessed with unbreakable skin and super strength due to a prison experiment that went awry. As the show begins, he is hiding out in Harlem after the events of "Jessica Jones." He tries to keep a low profile, but cannot sit idly by as the community is torn apart by crime.
The show's main villain, Cornell (don't call him Cottonmouth) runs most of the rackets in Harlem out of his nightclub, Harlem's Paradise. But his operation starts to unravel when a gun deal goes south and Luke Cage starts to investigate him.
Det. Misty Knight
Knight is a no-nonsense cop who grew up in the streets of Harlem. She starts investigating when reports of a man with super strength begin surfacing, putting her on a collision course with Cage.
Fans of the Marvel/Netflix universe will remember Temple as the nurse who assisted both Daredevil and Jessica Jones. She takes up the same role here, this time offering help and guidance to Cage.
Willis "Diamondback" Stryker
(Erik LaRay Harvey)
Little has been revealed about Diamondback thus far, other than he is a highly-feared criminal who provides support to Cottonmouth when needed. In the comics, he is an old friend of Cage's who is a master of knives.