Bill Hader, Kristen Wiig Bond as Brother and Sister in ‘The Skeleton Twins’ Trailer (Video)

Luke Wilson co-stars as Wiig’s husband, who she cheats on with a SCUBA instructor played by Boyd Holbrook

Bill Hader plays a gay man who tries to rekindle his relationship with his twin sister, played by Kristen Wiig, after 10 years apart in a new trailer for “The Skeleton Twins.”

The comedic drama (some might call it a “dramedy,” if they like smashing words together) premiered at the Sundance Film Festival earlier this year, and won Best Screenplay while competing in the U.S. Dramatic category.

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The former “Saturday Night Live” co-stars are joined on screen by Luke WilsonTy Burrell and Boyd Holbrook as they try to sort out problems in their lives and their sibling relationship.

“Skeleton Twins” hits theaters on Sept. 19.