Reading Sean Penn's interview with Joaquin "El Chapo" Guzm\u00e1n, you may have gotten the impression he's just a courteous, peaceful family man who only ran the Sinaloa Cartel to support his loved ones -- kind of a Mexican Tony Soprano.\r\n"Look, all I do is defend myself, nothing more," he told Penn. "But do I start trouble? Never."\r\nProsecutors in the U.S. and other countries beg to disagree. They contend that Guzm\u00e1n is an international crime lord whose drug business has cost the Mexican government billions of dollars in resources, and contributed to the deaths of thousands.\r\nHere are four reasons that Guzm\u00e1n was, until his capture on Jan. 8, one of the most-wanted fugitives in the world.\r\nAlso Read: El Chapo Drama Series to Premiere Next Fall on Univision's UniM\u00e1s (Exclusive)\r\n1. He Is Accused of Killing 12 People\r\nAs is common in the drug trade, Guzm\u00e1n's empire was built in part through extreme violence. As many as 100,000 have died in the last decade in Mexico's drug wars, though it is impossible to estimate exactly how many have died because of the Sinaloa Cartel. The cartel, however, is notorious for its brutality. The group is said to behead rivals and dissolve the bodies in vats of acid, often posting images and video online as a warning.\r\nAs the Daily News reported in 2014, a U.S. indictment says charged Guzm\u00e1n and his successor "employed 'sicarios,' or hit men, who carried out hundreds of acts of violence, including murders, assaults, kidnappings, assassinations and acts of torture." Guzm\u00e1n was charged with 12 murders.\r\n2. He Was the Biggest Drug Trafficker Since Pablo Escobar\r\nAccording to several drug enforcement agencies -- and Guzm\u00e1n himself - he supplied half of all of the cocaine, marijuana, methamphetamine, and heroin that comes into the United States. That would mean his drug empire surpassed that of even the infamous Pablo Escobar, who was killed by Colombian and U.S. authorities in 1993.\r\n3. He Escaped from Prison. Twice\r\nGuzm\u00e1n has become an almost mythical figure in Mexico for escaping from maximum security prison on two separate occasions. He was first locked up for drug trafficking and murder in 1993. However, Guzm\u00e1n was living the high life in his prison cell, thanks to bribes paid out to various prison officials, including the prison's warden. He escaped after being released from his cell and hiding in a laundry cart in 2001.\r\nGuzm\u00e1n was re-captured in 2014, but achieved his second escape in 2015 with an even more elaborate escape. After he disappeared, officials found a tunnel measuring almost one mile in length beneath his cell, which was fitted with a track made to accommodate a motorcycle that he used to flee.\r\nAlso Read: 7 Takeaways From Sean Penn's Rolling Stone Interview With El Chapo\r\n4. He Made Forbes List of the World's Most Powerful People\r\nHe has influence and reach. In 2009, 2010, and 2011, Guzm\u00e1n was included on the Forbes list of the most powerful people in the world. The business publication estimated that his narco-empire was worth upwards of $3 billion. Forbes decided not to include Guzm\u00e1n on later lists, because his money comes from illicit sources.