First ‘Scream Queens’ Trailer Has Lea Michele, Ariana Grande Fighting Red-Faced Killer (Video)

The new Fox anthology horror series comes from “Glee” and “American Horror Story” creator Ryan Murphy

In the first official trailer for Fox’s “Scream Queens” series, several sorority sisters find themselves at the mercy of a mysterious killer in a red mask.

Ariana Grande and Lea Michele star in the show, which sees a killer preying on college students on the 20th anniversary of a sorority pledge gone wrong.

In the trailer, we also get our first look at horror icon Jamie Lee Curtis as the school’s dean. Curtis previously starred in the “Halloween” franchise, as well as horror films “Prom Night” and “Terror Train.”

Ryan Murphy created “Scream Queens” and will serve as writer and executive producer. Murphy previously co-created “Glee” for Fox, which also starred Michele, and “American Horror Story,” currently entering its fifth season on FX. Murphy will also executive produce and write the upcoming anthology drama “American Crime Story.”

Watch the video above.