ABC/Eric McCandless

One thing every doctor at Grey Sloan Memorial Hospital grapples with at some point on “Grey’s Anatomy” is deciding their specialty. There have been doctors who come in knowing exactly what they want, like Cristina Yang (Sandra Oh), and doctors who change their minds several times — we’re looking at you, Meredith Grey (Ellen Pompeo).

It sounds like in Season 15, it will be Jo Wilson’s (Camilla Luddignton) turn to find her specialty.

“There are actually some decisions that will get made in the two-hour premiere,” Luddington recently told TheWrap of Jo’s upcoming career moves. “One of the things that does happen on the honeymoon is that Jo becomes inspired by what she believes could be a new medical innovation, and she decides that she wants to work on it with Meredith. And she ends up having to go back to Seattle and try and pitch the idea and it sort of segues into inspiring what she wants to do as a specialty. So you see in the two-hour premiere what direction she’s doing in, but then the question of Boston is still hanging in the air.”

Also Read: 'Grey's Anatomy': Meredith and DeLuca Get it On in Season 15 Teaser (Video)

Fans will remember Jo debating whether or not to move from Seattle to Boston in the Season 14 finale. Jo was admitted into a fellowship at Massachusetts General Hospital, but Meredith — in an effort to keep Jo from moving across the country with Alex Karev (Justin Chambers) — offers her a job at Grey Sloan.

The beginning of Season 15 will see Jo and Alex on their honeymoon… but it might not be all smooth sailing. The log line for the first hour, titled “With a Wonder and a Wild Desire,” says “Jo and Alex’s honeymoon doesn’t go exactly as planned.”

“There’s no massive disaster that happens, I’ll let you know that. But I think it’s just that it’s not as romantic as initially intended,” Luddington teased.

“Grey’s Anatomy” Season 15 premieres Sept. 27 on ABC.

Phil Owen contributed to this report.

'Grey's Anatomy': Elizabeth Moss, Sarah Paulson and 9 More Stars You Forgot Appeared on the Show (Photos)

With news that Geena Davis will reprise her role on "Grey's Anatomy" before the season's over, TheWrap takes a look back at other stars with roles on the longstanding medical drama.
ABC
Kyle Chandler

Honestly, who could forget Coach Taylor's appearance on "Grey's Anatomy" as bomb squad leader Dylan Young? Chandler appeared in Seasons 2 and 3 -- he guested on "Grey's" the same year that "Friday Night Lights" debuted on NBC.
ABC
Jeffrey Dean Morgan

Long before he was wielding a bat in the apocalypse of "The Walking Dead," Jeffrey Dean Morgan played one of "Grey's Anatomy"'s most tragic and beloved figures. Denny Duquette was the love interest to Izzy Stevens (Katherine Heigl) in Season 2, and their relationship inspired the interns to perform a questionable procedure on Denny's heart.
ABC
Scott Foley

Shondaland fans will recognize this face from another ABC drama. But before he played the sexy Jake Ballard on "Scandal," Foley played Henry Burton, a dying patient without insurance who Teddy (Kim Raver) ends up marrying so he could have surgery. "Scandal" stars Bellamy Young, Josh Malina and Katie Lowes have also made appearances on "Grey's."
ABC
Sarah Paulson

The "American Crime Story" star played Meredith's mother Dr. Ellis Grey in a flashback episode in Season 6, "The Time Warp." The episode revealed more about Ellis' relationship with Dr. Richard Webber.
ABC
Faye Dunaway

The "Network" star had a guest spot in Season 5 of "Grey's Anatomy" as Dr. Margaret Campbell, one of the original surgeons at the hospital who comes back to help in the OR.
ABC
Demi Lovato

The pop star made an appearance on "Grey's Anatomy" during her "Sonny With a Chance" days as Hayley May in a guest role during Season 6.
ABC
Mandy Moore

Now one of the stars of "This Is Us," Mandy Moore guest-starred in one of the most-talked about episodes in "Grey's" history. She played a pregnant patient in the active shooter episodes in Season 6.
ABC
Elisabeth Moss

The "Handmaid's Tale" star had a guest role in Season 3 of "Grey's" as Nina Rogerson, the daughter of a patient.
ABC
Zach Gilford

Kyle Chandler isn't the only "Friday Night Lights" alum to make an appearance on the ABC medical drama. Zach Gilford popped up in Season 5 as a soldier trying to get in healthy enough condition to return to the field. (And Jesse Plemmons made an appearance in Season 2).
ABC
Leslie Odom Jr.

The Grammy- and Tony-winning "Hamilton" star made an appearance on the small screen way back in Season 5. He played P.J. Walling, a participant in a domino surgery.
ABC

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Mandy Moore, anyone?

With news that Geena Davis will reprise her role on "Grey's Anatomy" before the season's over, TheWrap takes a look back at other stars with roles on the longstanding medical drama.

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