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James Gandolfini Death: Hollywood Reacts to ‘The Sopranos’ Star’s Passing (Video)

The 51-year-old actor died while on vacation in Rome, Italy

James Gandolfini's death at 51-years-old hit the industry like a ton of bricks on Wednesday.

"The Sopranos" star died while on vacation in Rome, an HBO spokeswoman confirmed to TheWrap. Cause of death hasn't been confirmed, though reports have said he died of possible heart attack.

HBO released the following statement:

We're all in shock and feeling immeasurable sadness at the loss of a beloved member of our family. He was special man, a great talent, but more importantly a gentle and loving person who treated everyone no matter their title or position with equal respect. He touched so many of us over the years with his humor, his warmth and his humility. Our hearts go out to his wife and children during this terrible time. He will be deeply missed by all of us.

See video: 10 of Tony Soprano's Most Memorable Moments

"Our hearts are shattered and we will miss him deeply," the actor's managers, Mark Armstrong and Nancy Sanders, said in a joint statement. "He and his family were part of our family for many years and we are all grieving."

Gandolfini had recently filmed "Criminal Justice" for HBO, which had received a limited series order.

He had won three Emmys, three Screen Actors Guild Awards and a Golden Globe for the HBO mob series, in which he played Tony Soprano, a beleaguered mob boss with mom issues. The burly actor specialized in playing brusque, intimidating guy's guys whose big frames concealed generous hearts.

Hollywood poured its condolences out on Twitter. Here's a sample of the reactions.