"What does it feel like to be both an adjective and a verb for 'child star gone wrong'?" Winfrey continues in the 16-second clip.
The exclusive interview will air Aug. 18 at 9 p.m. ET on OWN.
Lohan does not have any dialogue in the first-look trailer itself; she just sits there in an orange dress with her hair pulled back in a ponytail, cocking her head, breathing and preparing answers.
Watch the short teaser, just don't blink: