Queen Latifah and Jada Pinkett Smith are in final negotiations for the lead roles in the Universal comedy “Girl Trip,” TheWrap has learned.

Malcolm Lee (“The Best Man Holiday,” “Barbershop 3”) will be direct.

Regina Hall, who was previously cast in the film, will also star.

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“Girl Trip” revolves around four friends on a trip to New Orleans during the yearly Essence Festival. The group of women rekindle their friendship, get wild on the dance floor (and a little drunk), find romance and even get into a brawl.

While Latifah and Pinkett Smith have been working together as producers on films like “Secret Life” and “Dear Mama,” “Girl Trip” marks the first time the two have appeared in a film together since the 1996 crime drama “Set it Off,” directed by F. Gary Gray.

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The film is set to open July 21, 2017.

Will Packer (“Ride Along,” “No Good Deed”) will produce through his Will Packer Productions banner and James Lopez will executive produce.

Kenya Barris, creator of the hit comedy series “Black-ish,” and Tracy Oliver wrote the screenplay.

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Vice president of production Sara Scott will oversee the project on behalf of Universal.

Pinkett Smith is represented by Paradigm, managers Miguel Melendez and James Lassiter, and Sloane, Offer, Weber & Dern.

Latifah is represented by CAA, Principato-Young Entertainment, and Eisenberg, Tanchum & Levy.

13 Hollywood Besties Who Starred in Movies Together Before 'Sisters' Tina Fey and Amy Poehler (Photos)

Matt Damon and Ben Affleck
The two actors became friends when they were children and lived two blocks away from each other in Boston. The duo won a Best Screenplay Oscar in 1988 for their film, "Good Will Hunting," in which they also starred. The best friends also starred in "Dogma" together.
MIramax Films
Kristen Wiig and Maya Rudolph
The two friends and "Saturday Night Live" alums starred in "Bridesmaids" and "Friends with Kids" together.

Universal Pictures
Will Ferrell and John C. Reilly
The two comedians really hit it off on the set of "Talladega Nights" in 2006, and have since starred in "Step Brothers" and "Anchorman 2" together.
Sony
Kate Hudson and Liv Tyler
Hudson and Tyler starred in the 2000 film, "Dr. T and the Woman" together, but the two are actually best pals in real life and went to the same high school.
Artisan Entertainment
Zac Efron and Dave Franco
Efron and Franco are friends in real life, but also played best friends and frat bros in "Neighbors," and co-starred in "Charlie St. Cloud."
Universal
Ansel Elgort and Nat Wolff
Real-life buddies Elgort and Wolff starred in "The Fault in Our Stars" together, and Elgort even made a small appearance in Wolff's latest film, "Paper Towns."
Fox 2000
Selena Gomez and Vanessa Hudgens
Hudgens called Gomez one of her best friends in a National Best Friend Day Instagram post this year, and the two starred in "Spring Breakers" together.
A24
Brad Pitt and George Clooney
Pitt and Clooney played partners in crime in "Ocean's Eleven," but are also good pals in real life, riding motorcycles together when Pitt visits Clooney at Lake Como.
Warner Bros.
James Franco and Seth Rogen
Their friendship began when they both were cast in the 1999 series, "Freaks and Geeks." Since then, the bromantic friends have teamed up for "This is the End," "The Interview" and "Pineapple Express."
Sony
Ben Stiller and Owen Wilson
Not only have Stiller and Wilson been in over 10 movies together, which include "Night at the Museum," "Meet the Parents" and "Zoolander," but they have also been friends for a long time.
Paramount
Leonardo DiCaprio and Tobey Maguire
The two actors have been friends for over 25 years, which started when the pair auditioned for a lot of the same roles. Recently, they starred in "The Great Gatsby" together, but also worked on "Don's Plum" and "This Boy's Life" together.
Warner Bros.
Kevin James and Adam Sandler
Adam Sandler is known to make movies with his best friends, and Kevin James is one of them. They two did "I Now Pronounce You Chuck & Larry," "Grown Ups," and "Pixels" together, to name a few.
Universal
Drew Barrymore and Cameron Diaz
The two became friends during their "Charlie's Angels" days, and have been inseparable ever since.
Columbia

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The real-life best friends reunited for another comedy after starring in “Baby Mama” together. Here are over a dozen more BFFs who have shared the big screen together.

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