Players are only allowed to give a one-word clue to their partner in order to guess the password.
With words like “wax,” “opera” and “brunch” popping up, Lowe and Fallon took an early lead over the CBS sitcom stars.
The women started to make a comeback, but were stumped by the word “cringe” and some dramatic miming allowed the guys to clinch a victory.
“The Grinder” premieres on Tuesday at 8:30 p.m. ET on Fox.
“The Tonight Show” airs at 11:35 p.m. on NBC.