The show, from the Emmy-winning team comprised of "Robot Chicken" head writer Tom Root and co-creator Matthew Senreich, will satirize 1980s Japanese cartoons.
Seth Green will voice the title role of the villain and will serve as an executive producer. He is also one of the creators of "Robot Chicken."
Other actors lending their voices the the show include Breckin Meyer, Rachael Leigh Cook, Dan Milano and Eden Espinosa.
"Robot Chicken" has been on air for four seasons and features childhood action figures acting out parodies of pop culture fodder.
"Titan Maximum" premieres on Sept. 27 at 11:30 p.m. ET.