O’Brien asked the “Community” actor and E!’s “The Soup” host if he’s interested in the job.
“[Expletive] no, who would do that?” grinning at O’Brien. “I mean that is so much work, right?”
He later continued, “No, I’m funny about once a week. And, hey, I’m on the E! Network, where can I go higher from there?”
McHale also addressed a photo he took with CBS CEO Les Moonves and his wife, “The Talk’s” Julie Chen, which got tongues wagging.
“It was a [expletive] picture!” McHale told O’Brien. “She tweeted it and then I retweeted it and the entertainment business assumed, ‘Well, that’s a contract.'”
In April, Ferguson announced his impending departure from CBS’s 12:35 p.m. talk show. Soon after, McHale found his name floated in the media as a possible replacement for Ferguson, alongside Aisha Tyler and Chris Hardwick, among others.
Watch the video above and decide for yourself how sincere McHale was being about the late night gig.